Article
Discovery of the improved antagonistic prolactin variants by library screening.
Protein engineering, design & selection : PEDS - 1 Nov 2011
Liu Yun, Gong Wei, Breinholt Jens, Nørskov-Lauritsen Leif, Zhang Jinchao, Ma Qinhong, Chen Jianhe, Panina Svetlana, Guo Wei, Li Tengkun, Zhang Jingyuan, Kong Meng, Liu Zibing, Mao Jingjing, Christensen Leif, Hu Sean, Wang Lingyun
Abstract excerpt
Prolactin (PRL), a potent growth stimulator of the mammary epithelium, has been suggested to be a factor contributing to the development and progression of breast and prostate cancer. Several PRL receptor (PRLR) antagonists have been identified in the past decades, but their in vivo growth inhibitory potency was restricted by low receptor affinity, rendering them pharmacologically unattractive for clinical...
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