Flow cytometric analysis of the multiple drug resistance phenotype.

doi:10.1038/sj.leu.2400684

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Article

Flow cytometric analysis of the multiple drug resistance phenotype.

Leukemia - 1 Jul 1997

Krishan A, Sauerteig A, Andritsch I, Wellham L

Abstract excerpt

Laser flow cytometry is increasingly used for quantitation of cellular fluorescent drug retention, effect of efflux blockers and for expression of drug resistance related cellular surface markers. Several intrinsic and extrinsic factors can affect the results obtained from drug retention functional assays and lead to artifacts. In the present study, we have used a panel of well-characterized parental and drug...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Daunorubicin
Drug Resistance, Multiple
Flow Cytometry
Fluorescence
Humans
Lymphocytes
Mice
Phenotype
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 9205003
DOI: 10.1038/sj.leu.2400684

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