Analysis of the tangled relationships between P‐glycoprotein‐mediated multidrug resistance and the lipid phase of the cell membrane

Abstract excerpt

P-glycoprotein (Pgp), the so-called multidrug transporter, is a plasma membrane glycoprotein often involved in the resistance of cancer cells towards multiple anticancer agents in the multidrug-resistant (MDR) phenotype. It has long been recognized that the lipid phase of the plasma membrane plays an important role with respect to multidrug resistance and Pgp because: the compounds involved in the MDR phenotype...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Drug Transport and Resistance Mechanisms
• Share to Pediatric Hepatobiliary Diseases and Treatments
• Share to Pharmacological Effects and Toxicity Studies