Mammalian DNA topoisomerase IIIalpha is essential in early embryogenesis.

doi:10.1073/pnas.95.3.1010

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Article

Mammalian DNA topoisomerase IIIalpha is essential in early embryogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 3 Feb 1998

Li W, Wang J C

Abstract excerpt

Targeted disruption of the mouse TOP3alpha gene encoding DNA topoisomerase IIIalpha was carried out to study the physiological functions of the mammalian type IA DNA topoisomerase. Whereas heterozygous top3alpha+/- mutant mice were found to resemble phenotypically their TOP3alpha+/+ litermates, n...

Topics

Animals
Blastocyst
Brain
Cells, Cultured
Culture Techniques
DNA Topoisomerases, Type I
Embryonic Development
Embryonic and Fetal Development
Female
Genotype
Mice
Pregnancy
Stem Cells

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