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Article

Mammalian DNA topoisomerase IIIalpha is essential in early embryogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 3 Feb 1998

Li W, Wang J C

Abstract excerpt

Targeted disruption of the mouse TOP3alpha gene encoding DNA topoisomerase IIIalpha was carried out to study the physiological functions of the mammalian type IA DNA topoisomerase. Whereas heterozygous top3alpha+/- mutant mice were found to resemble phenotypically their TOP3alpha+/+ litermates, no viable top3alpha-/- homozygotes were found among over 100 progeny of top3alpha+/- intercrosses. Examination of...

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Identifiers

PMID: 9448276
DOI: 10.1073/pnas.95.3.1010
PMCID: PMC18654

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