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Mice lacking DNA topoisomerase IIIβ develop to maturity but show a reduced mean lifespan

1 May 2001

Abstract excerpt

Targeted gene disruption in the murine TOP3beta gene-encoding DNA topoisomerase IIIbeta was carried out. In contrast to the embryonic lethality of mutant mice lacking DNA topoisomerase IIIalpha, top3beta(-/-) nulls are viable and grow to maturity with no apparent defects. Mice lacking DNA topoisomerase IIIbeta have a shorter life expectancy than their wild-type littermates, however. The mean lifespan of the...

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PMID: 11331780
DOI: 10.1073/pnas.101132498

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