Article
Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants.
BMC developmental biology - 23 Nov 2011
Sapetto-Rebow Beata, McLoughlin Sarah C, O'Shea Lynne C, O'Leary Olivia, Willer Jason R, Alvarez Yolanda, Collery Ross, O'Sullivan Jacintha, Van Eeden Freek, Hensey Carmel, Kennedy Breandán N
Abstract excerpt
BACKGROUND: Genetic alterations in human topoisomerase II alpha (TOP2A) are linked to cancer susceptibility. TOP2A decatenates chromosomes and thus is necessary for multiple aspects of cell division including DNA replication, chromosome condensation and segregation. Topoisomerase II alpha is also required for embryonic development in mammals, as mouse Top2a knockouts result in embryonic lethality as early as the...
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