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Article

The high-mobility-group box protein SSRP1/T160 is essential for cell viability in day 3.5 mouse embryos.

Molecular and cellular biology - 1 Aug 2003

Cao Shang, Bendall Heather, Hicks Geoffrey G, Nashabi Abudi, Sakano Hitoshi, Shinkai Yoichi, Gariglio Marisa, Oltz Eugene M, Ruley H Earl

Abstract excerpt

The high-mobility-group (HMG) SSRP1 protein is a member of a conserved chromatin-remodeling complex (FACT/DUF/CP) implicated in DNA replication, basal and regulated transcription, and DNA repair. To assist in the functional analysis of SSRP1, the Ssrp1 gene was targeted in murine embryonic stem cells, and the mutation was introduced into the germ line. Embryos homozygous for the targeted allele die soon after...

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Identifiers

PMID: 12861016
DOI: 10.1128/MCB.23.15.5301-5307.2003
PMCID: PMC165710

Genes

SSRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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