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Article

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection.

Molecular and cellular biology - 1 Dec 1996

Morham S G, Kluckman K D, Voulomanos N, Smithies O

Abstract excerpt

Topoisomerase I has ubiquitous roles in important cellular functions such as replication, transcription, and recombination. In order to further characterize this enzyme in vivo, we have used gene targeting to inactivate the mouse Top-1 gene. A selection protocol using the topoisomerase I inhibito...

Topics

Alleles
Animals
Camptothecin
DNA Topoisomerases, Type I
Enzyme Inhibitors
Female
Gene Expression Regulation, Developmental
Gene Targeting
Mice
Pregnancy
Topoisomerase I Inhibitors
Transfection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8943335
DOI: 10.1128/MCB.16.12.6804
PMCID: PMC231683

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8943335-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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