Article

Topoisomerase IIIβ protects from tumorigenesis and immune dysregulation

2025-03-15

Abstract excerpt

Topoisomerase III-beta (Top3b) reduces nucleic acid torsional stress and intertwining generated during RNA and DNA metabolism while protecting the genome from pathological R-loops, which otherwise result in DNA breakage and genome instability. By studying Top3b knockout mice (Top3b-KO), we find that the loss of Top3b accelerates the development of spontaneous lymphoid tumors arising in spleens and lymph nodes, the...

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Literature Corpus work: cbcbae02-a17b-5817-b957-48f5db7e03fb
DOI: 10.1101/2025.03.13.643061

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