Article

RNA Targets and Physiological Role of Topoisomerase 3β

2023-05-25

Abstract excerpt

Topoisomerase 3β (Top3β) works not only on DNA but also RNA. We isolated and identified the naturally cross-linked RNA targets of Drosophila Top3β from an early embryonic stage that contains almost exclusively maternal mRNAs. Favorite targets were longer RNAs, RNAs with many splice sites, and RNAs that become localized in large cells. Demonstrating the importance of its enzymatic activity, Top3β without the hydrox...

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Literature Corpus work: e664854b-9d66-5941-9278-713d25c127eb
DOI: 10.1101/2023.05.25.542246

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