Article
Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius.
Nature biotechnology - 1 Jan 1998
Madduri K, Kennedy J, Rivola G, Inventi-Solari A, Filippini S, Zanuso G, Colombo A L, Gewain K M, Occi J L, MacNeil D J, Hutchinson C R
Abstract excerpt
A fermentation method that bypasses the low-yielding semisynthesis of epirubicin (4'-epidoxorubicin) and 4'-epidaunorubicin, important cancer chemotherapy drugs, has been developed for Streptomyces peucetius. This bacterium normally produces the anthracycline antibiotics, doxorubicin and daunorub...
Topics
- Antibiotics, Antineoplastic
- DNA Primers
- Epirubicin
- Fermentation
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Genetic Engineering
- Genotype
- Hexosamines
- Mutation
- Plasmids