Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius.

Nature biotechnology - 1 Jan 1998

Madduri K, Kennedy J, Rivola G, Inventi-Solari A, Filippini S, Zanuso G, Colombo A L, Gewain K M, Occi J L, MacNeil D J, Hutchinson C R

Abstract excerpt

A fermentation method that bypasses the low-yielding semisynthesis of epirubicin (4'-epidoxorubicin) and 4'-epidaunorubicin, important cancer chemotherapy drugs, has been developed for Streptomyces peucetius. This bacterium normally produces the anthracycline antibiotics, doxorubicin and daunorubicin; the 4'-epimeric anthracyclines are formed by introducing the heterologous Streptomyces avermitilis avrE or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Primers
Share to Fermentation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Bacterial

Share to Genes, Bacterial

Share to Genotype

Share to Mutation

Share to Plasmids

Share to Streptomyces

Source

Identifiers

PMID: 9447597
DOI: 10.1038/nbt0198-69

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius.PMID 9447597Read ↗

Genetic engineering of doxorubicin production in Streptomyces peucetius : a reviewSemantic proximity Read ↗

Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N-dimethylated anthracyclinesSemantic proximity Read ↗

One-Pot Combinatorial Biosynthesis of Glycosylated Anthracyclines by Cocultivation of Streptomyces Strains Producing Aglycones and Nucleotide Deoxysugars.Semantic proximity Read ↗

Enhanced doxorubicin production by Streptomyces peucetius using a combination of classical strain mutation and medium optimization.Semantic proximity Read ↗

A multiplasmid approach to preparing large libraries of polyketides.Semantic proximity Read ↗

Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.Semantic proximity Read ↗

Engineered biosynthesis of a complete macrolactone in a heterologous host.Semantic proximity Read ↗

Engineered biosynthesis of glycosylated derivatives of narbomycin and evaluation of their antibacterial activities.Semantic proximity Read ↗

Control of avermectin biosynthesis in Streptomyces avermitilis for the selective production of a useful component.Semantic proximity Read ↗

Biosynthesis of the enediyne antitumor antibiotic C-1027.Semantic proximity Read ↗

Semi-synthetic DNA shuffling of aveC leads to improved industrial scale production of doramectin by Streptomyces avermitilis.Semantic proximity Read ↗

Ketosynthase III as a gateway to engineering the biosynthesis of antitumoral benastatin derivatives.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.