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Genetic engineering of doxorubicin production in Streptomyces peucetius : a review

1 Jul 1999

Abstract excerpt

The genetics and biochemistry of daunorubicin and doxorubicin production by Streptomyces peucetius is reviewed, with a focus on how such information can be used for the genetic engineering of strains having improved titers of these two antitumor antibiotics.

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Identifiers

PMID: 10455495
DOI: 10.1038/sj.jim.2900673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic engineering of doxorubicin production in Streptomyces peucetius : a reviewPMID 10455495Read ↗

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Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius.Semantic proximity Read ↗

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Self-resistance mechanism in Streptomyces peucetius: Overexpression of drrA, drrB and drrC for doxorubicin enhancementSemantic proximity Read ↗

Isolation and characterization of stable mutants of Streptomyces peucetius defective in daunorubicin biosynthesis.Semantic proximity Read ↗

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Isolation of a chitinase overproducing mutant of Streptomyces peucetius defective in daunorubicin biosynthesis.Semantic proximity Read ↗

Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesisSemantic proximity Read ↗

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