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Enhanced doxorubicin production by Streptomyces peucetius using a combination of classical strain mutation and medium optimization.

Preparative biochemistry & biotechnology - 1 Jan 2018

Wang Xiaoru, Tian Xiaorong, Wu Yuanjie, Shen Xiaofang, Yang Songbai, Chen Shaoxin

Abstract excerpt

Doxorubicin (DXR), which is produced by Streptomyces peucetius, is an important anthracycline-type antibiotic used for the treatment of various cancers. However, due to the low DXR productivity of wild-type S. peucetius, it is difficult to produce DXR by one-step fermentation. In this study, a DXR-resistance screening method was developed to screen for DXR high-producing mutants. Then, S. peucetius SIPI-11 was...

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PMID: 29939834
DOI: 10.1080/10826068.2018.1466156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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