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Article

Biosynthesis of the enediyne antitumor antibiotic C-1027.

Science (New York, N.Y.) - 16 Aug 2002

Liu Wen, Christenson Steven D, Standage Scott, Shen Ben

Abstract excerpt

C-1027 is a potent antitumor agent with a previously undescribed molecular architecture and mode of action. Cloning and characterization of the 85-kilobase C-1027 biosynthesis gene cluster from Streptomyces globisporus revealed (i) an iterative type I polyketide synthase that is distinct from any bacterial polyketide synthases known to date, (ii) a general polyketide pathway for the biosynthesis of both the 9-...

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Source

Identifiers

PMID: 12183628
DOI: 10.1126/science.1072110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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