Article
Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.
Journal of bacteriology - 1 Jan 1999
Lomovskaya N, Otten S L, Doi-Katayama Y, Fonstein L, Liu X C, Takatsu T, Inventi-Solari A, Filippini S, Torti F, Colombo A L, Hutchinson C R
Abstract excerpt
Doxorubicin-overproducing strains of Streptomyces peucetius ATCC 29050 can be obtained through manipulation of the genes in the region of the doxorubicin (DXR) gene cluster that contains dpsH, the dpsG polyketide synthase gene, the putative dnrU ketoreductase gene, dnrV, and the doxA cytochrome P-450 gene. These five genes were characterized by sequence analysis, and the effects of replacing dnrU, dnrV, doxA, or...
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