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Article

One-Pot Combinatorial Biosynthesis of Glycosylated Anthracyclines by Cocultivation of Streptomyces Strains Producing Aglycones and Nucleotide Deoxysugars.

ACS combinatorial science - 10 Apr 2017

Kim Eunji, Song Myoung Chong, Kim Myoun Su, Beom Ji Yoon, Jung Jin A, Cho Hang Soo, Yoon Yeo Joon

Abstract excerpt

Anthracyclines, such as doxorubicin, are effective anticancer drugs composed of a tetracyclic polyketide aglycone and one or more deoxysugar moieties, which play a critical role in their biological activity. A facile one-pot combinatorial biosynthetic system was developed for the generation of a range of glycosylated derivatives of anthracyclines. Cocultivation of Streptomyces venezuelae mutants producing two...

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PMID: 28191923
DOI: 10.1021/acscombsci.6b00194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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