Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interactions between SH2 and SH3 domains.

Biochemical and biophysical research communications - 14 Jan 1998

Vihinen M, Smith C I

Abstract excerpt

Src homology 2 (SH2) and SH3 domains are abundant protein and peptide binding modules in signalling molecules. Certain SH2 and SH3 domains have been shown to form functional and physical interactions. The structural basis of dimer formation was studied by docking three dimensional structures of the domains and by analysing structural and functional properties of the dimers. The experimentally verified dimers were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Protein-Tyrosine Kinases
Share to Protein Conformation
Share to Dimerization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrogen Bonding

Share to Models, Molecular

Share to Mutation

Share to Phosphorylation

Share to Phosphotyrosine

Source

Identifiers

PMID: 9446798
DOI: 10.1006/bbrc.1997.7909

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interactions between SH2 and SH3 domains.PMID 9446798Read ↗

SH3-like fold proteins are structurally conserved and functionally divergent.Semantic proximity Read ↗

Diversity in the SH2 domain family phosphotyrosyl peptide binding site.Semantic proximity Read ↗

A Systematic Compilation of Human SH3 Domains: A Versatile Superfamily in Cellular SignalingSemantic proximity Read ↗

SH2db, an information system for the SH2 domainSemantic proximity Read ↗

From Binding-Induced Dynamic Effects in SH3 Structures to Evolutionary Conserved Sectors.Semantic proximity Read ↗

The combination of hydrogen/deuterium exchange or chemical cross-linking techniques with mass spectrometry: mapping of human 14-3-3ζ homodimer interface.Semantic proximity Read ↗

Insights into the folding and unfolding processes of wild-type and mutated SH3 domain by molecular dynamics and replica exchange molecular dynamics simulations.Semantic proximity Read ↗

Crystal structure of the SH3 domain in human Fyn; comparison of the three‐dimensional structures of SH3 domains in tyrosine kinases and spectrin.Semantic proximity Read ↗

Structural basis for PDZ domain interactions in the post-synaptic density scaffolding protein Shank3.Semantic proximity Read ↗

Investigation of binding phenomenon of NSP3 and p130Cas mutants and their effect on cell signalling.Semantic proximity Read ↗

Determining folding and binding properties of the C-terminal SH2 domain of SHP2.Semantic proximity Read ↗

IgG2 Fc structure and the dynamic features of the IgG CH2-CH3 interface.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.