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Article

Investigation of binding phenomenon of NSP3 and p130Cas mutants and their effect on cell signalling.

Cell biochemistry and biophysics - 1 Nov 2013

Balu K, Rajendran Vidya, Sethumadhavan Rao, Purohit Rituraj

Abstract excerpt

Members of the novel SH2-containing protein (NSP3) and Crk-associated substrate (p130Cas) protein families form a multi-domain signalling platforms that mediate cell signalling process. We analysed the damaging consequences of three mutations, each from NSP3 (NSP3(L469R), NSP3(L623E), NSP3(R627E)) and p130Cas (p130Cas(F794R), p130Cas(L787E), p130Cas(D797R)) protein with respect to their native biological...

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PMID: 23494262
DOI: 10.1007/s12013-013-9551-6

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