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Article

From Binding-Induced Dynamic Effects in SH3 Structures to Evolutionary Conserved Sectors.

PLoS computational biology - 1 May 2016

Zafra Ruano Ana, Cilia Elisa, Couceiro José R, Ruiz Sanz Javier, Schymkowitz Joost, Rousseau Frederic, Luque Irene, Lenaerts Tom

Abstract excerpt

Src Homology 3 domains are ubiquitous small interaction modules known to act as docking sites and regulatory elements in a wide range of proteins. Prior experimental NMR work on the SH3 domain of Src showed that ligand binding induces long-range dynamic changes consistent with an induced fit mechanism. The identification of the residues that participate in this mechanism produces a chart that allows for the...

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PMID: 27213566
DOI: 10.1371/journal.pcbi.1004938
PMCID: PMC4877006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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