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Article

Determining folding and binding properties of the C-terminal SH2 domain of SHP2.

Protein science : a publication of the Protein Society - 1 Dec 2021

Nardella Caterina, Malagrinò Francesca, Pagano Livia, Rinaldo Serena, Gianni Stefano, Toto Angelo

Abstract excerpt

SH2 domains are a class of protein-protein interaction modules with the function to recognize and bind sequences characterized by the presence of a phosphorylated tyrosine. SHP2 is a protein phosphatase involved in the Ras-ERK1/2 signaling pathway that possess two SH2 domains, namely, N-SH2 and C-SH2, that mediate the interaction of SHP2 with various partners and determine the regulation of its catalytic...

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Identifiers

PMID: 34605082
DOI: 10.1002/pro.4201
PMCID: PMC8605372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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