Article
Metabolic determinants are much more important than genetic polymorphisms in determining the PAI-1 activity and antigen plasma concentrations: a family study with part of the Stanislas Cohort.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 1998
Henry M, Tregouët D A, Alessi M C, Aillaud M F, Visvikis S, Siest G, Tiret L, Juhan-Vague I
Abstract excerpt
Increased plasma plasminogen activator inhibitor-1 (PAI-1) concentration has been identified as a risk factor for coronary heart disease. We investigated the relative contribution of both metabolic factors involved in the insulin resistance (IR) syndrome and polymorphisms of the PAI-1 gene to plasma levels of PAI-1 in 228 healthy nuclear white families from the Stanislas Cohort. Variables related to IR included...
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