PAI-1 polymorphisms modulate phenotypes associated with the metabolic syndrome in obese and diabetic Caucasian population.

doi:10.1007/s00125-003-1170-0

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Article

PAI-1 polymorphisms modulate phenotypes associated with the metabolic syndrome in obese and diabetic Caucasian population.

Diabetologia - 1 Sept 2003

Lopes C, Dina C, Durand E, Froguel P

Abstract excerpt

AIM/HYPOTHESIS: Plasminogen activator inhibitor-1 (PAI-1) is a main regulator of the endogenous fibrinolytic system and modulates the thrombosis progression. We analyzed genetic contributions of PAI-1 mutations to the metabolic syndrome and to its complications. METHODS: PAI-1 promoter and coding sequences were screened for mutations. Genotypes were determined for 1067 unrelated individuals of a French Caucasian...

Topics

Body Mass Index
Case-Control Studies
Cohort Studies
Coronary Disease
Diabetes Mellitus
Diabetic Angiopathies
Female
France
Genotype
Humans
Insulin
Insulin Secretion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Metabolic Syndrome

Middle Aged

Obesity

Pedigree

Phenotype

Source

Open in PubMed

Identifiers

PMID: 12856128
DOI: 10.1007/s00125-003-1170-0

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PAI-1 polymorphisms modulate phenotypes associated with the metabolic syndrome in obese and diabetic Caucasian population.PMID 12856128Read ↗

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