Article
Spectrum of p53 gene mutations suggests a possible role for ultraviolet radiation in the pathogenesis of advanced cutaneous lymphomas.
The Journal of investigative dermatology - 1 Mar 1999
McGregor J M, Crook T, Fraser-Andrews E A, Rozycka M, Crossland S, Brooks L, Whittaker S J
Abstract excerpt
There is evidence that the incidence of primary cutaneous lymphoma, like other forms of non-Hodgkin's lymphoma, is increasing, yet little is known of the pathogenetic events involved in this group of disorders. In this study we examine the frequency and spectrum of P53 gene mutations in a large series of primary cutaneous lymphomas, with particular emphasis on tumor stage mycosis fungoides, as it is in these...
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