Article
Frequent p53 accumulation in the chronically sun-exposed epidermis and clonal expansion of p53 mutant cells in the epidermis adjacent to basal cell carcinoma.
The Journal of investigative dermatology - 1 Jun 1995
Urano Y, Asano T, Yoshimoto K, Iwahana H, Kubo Y, Kato S, Sasaki S, Takeuchi N, Uchida N, Nakanishi H
Abstract excerpt
p53 expression was studied immunohistochemically to identify a precursor lesion of basal cell carcinoma (BCC) in the epidermis adjacent to BCC. With two different anti-p53 antibodies of CM1 and DO7, p53 expression was frequently detected in the epidermis adjacent to BCCs arising on the face and in the normal epidermis with usual sun exposure. In the epidermis adjacent to BCC, stained cells were occasionally...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- Carcinoma, Basal Cell
- Cell Division
- Child
- Child, Preschool
- Clone Cells
- Epidermal Cells