Article
Overexpression of p53 protein in basal cell carcinomas of human skin.
The American journal of pathology - 1 Jul 1992
Shea C R, McNutt N S, Volkenandt M, Lugo J, Prioleau P G, Albino A P
Abstract excerpt
Basal cell carcinoma (BCC) of the skin is the most common human cancer, but its molecular-genetic pathogenesis is unclear. In many other types of cancer, mutations of the tumor-suppressor gene p53 occur frequently and may lead to overexpression of a long-lived mutant form of p53 protein. In this study, overexpression of p53 protein was detected immunohistochemically in 30 (83%) of 36 specimens of BCC of the head...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
