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Article

Overexpression of p53 protein in basal cell carcinomas of human skin.

The American journal of pathology - 1 Jul 1992

Shea C R, McNutt N S, Volkenandt M, Lugo J, Prioleau P G, Albino A P

Abstract excerpt

Basal cell carcinoma (BCC) of the skin is the most common human cancer, but its molecular-genetic pathogenesis is unclear. In many other types of cancer, mutations of the tumor-suppressor gene p53 occur frequently and may lead to overexpression of a long-lived mutant form of p53 protein. In this study, overexpression of p53 protein was detected immunohistochemically in 30 (83%) of 36 specimens of BCC of the head...

Topics

Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal
Carcinoma, Basal Cell
Female
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Humans
Immunohistochemistry
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutation

Skin Neoplasms

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 1632467
PMCID: PMC1886589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1632467-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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