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Article

Contribution of enhanced transcriptional activation by ER to [12Val] K-Ras mediated NIH3T3 cell transformation.

Oncogene - 18 Dec 1997

Kato K, Ueoka Y, Kato K, Hachiya T, Nishida J, Wake N

Abstract excerpt

We investigated the biological significance of estrogen receptors (ER) in NIH3T3 cell transformation by the [12Val] K-Ras mutant. This mutant enhanced the steady state level of ER. Cells expressing mutant K-Ras (K12V cell) were tumorigenic. To determine the role of ER accumulation in Ras-transfor...

Topics

3T3 Cells
Animals
Cell Division
Cell Transformation, Neoplastic
Gene Expression Regulation, Neoplastic
Genes, ras
Mice
Mutation
Oligonucleotides, Antisense
Receptors, Estrogen
Receptors, Progesterone
Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcriptional Activation

Up-Regulation

ras Proteins

Source

Identifiers

PMID: 9444952
DOI: 10.1038/sj.onc.1201497

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9444952-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Contribution of enhanced transcriptional activation by ER to [12Val] K-Ras mediated NIH3T3 cell transformation.PMID 9444952Read ↗

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