Article
Overexpression of mitogen-activated protein kinase superfamily proteins unrelated to Ras and AF-1 of estrogen receptor alpha mutation in advanced stage human breast cancer.
Pathology, research and practice - 1 Jan 2000
Hori M, Inagawa S, Shimazaki J, Itabashi M, Hori M
Abstract excerpt
Transactivation of the activation function-1 (AF-1) region of the estrogen receptor alpha (ER-alpha) gene is regulated by pathway "cross-talk" from Ras mitogen-activated protein kinase (MAPK). An analysis of this system is important for solving the problem of resistance to anti-estrogen agents used in the treatment of human breast cancer. We investigated the ER-alpha and Ras gene mutations and the MAPK-related...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.