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Article

Efficient 3'-end formation of human beta-globin mRNA in vivo requires sequences within the last intron but occurs independently of the splicing reaction.

Nucleic acids research - 1 Feb 1998

Antoniou M, Geraghty F, Hurst J, Grosveld F

Abstract excerpt

The second intron (betaIVS-II) of the human beta-globin gene is essential for the accumulation of stable cytoplasmic mRNA and is implicated in promoting efficient 3'-end formation. This report presents quantitative comparisons between betaIVS-II mutants at physiological levels of expression from within a natural chromatin context in vivo which further defines it's function. In marked contrast to a beta-globin...

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Identifiers

PMID: 9443963
DOI: 10.1093/nar/26.3.721
PMCID: PMC147328

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