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Article

The tat/rev intron of human immunodeficiency virus type 1 is inefficiently spliced because of suboptimal signals in the 3' splice site.

Journal of virology - 1 May 1994

Staffa A, Cochrane A

Abstract excerpt

Proportional expression of retroviral genes requires that splicing of the viral primary transcript be an inefficient process. Much of our current knowledge about retroviral suboptimal splicing comes from studies with Rous sarcoma virus. In this report, we describe the use of chimeric introns composed of human beta-globin and human immunodeficiency virus type 1 (HIV-1) splice sites to establish the basis for...

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Identifiers

PMID: 7512159
DOI: 10.1128/JVI.68.5.3071-3079.1994
PMCID: PMC236797

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Source receipt: pubmed, retrieved 7 Sept 2026.

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