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Article

Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs.

The EMBO journal - 1 Feb 2001

Neu-Yilik G, Gehring N H, Thermann R, Frede U, Hentze M W, Kulozik A E

Abstract excerpt

Premature translation termination codons are common causes of genetic disorders. mRNAs with such mutations are degraded by a surveillance mechanism termed nonsense-mediated decay (NMD), which represents a phylogenetically widely conserved post-transcriptional mechanism for the quality control of gene expression. How NMD-competent mRNPs are formed and specified remains a central question. Here, we have used human...

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Identifiers

PMID: 11157759
DOI: 10.1093/emboj/20.3.532
PMCID: PMC133467

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