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Article

Ribozyme cleavage reveals connections between mRNA release from the site of transcription and pre-mRNA processing.

Molecular cell - 9 Dec 2005

Bird Gregory, Fong Nova, Gatlin Jesse C, Farabaugh Susan, Bentley David L

Abstract excerpt

We report a functional connection between splicing and transcript release from the DNA. A Pol II CTD mutant inhibited not only splicing but also RNA release from the site of transcription. A ribozyme situated downstream of the gene restored accurate splicing inhibited by the CTD mutant or a mutant poly(A) site, suggesting that cleavage liberates RNA from a niche that is inaccessible to splicing factors. Although...

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Identifiers

PMID: 16337598
DOI: 10.1016/j.molcel.2005.11.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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