Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A general statistical model for detecting complex-trait loci by using affected relative pairs in a genome search.

American journal of human genetics - 1 Apr 1996

Smalley S L, Woodward J A, Palmer C G

Abstract excerpt

Scanning of the human genome by use of affected relative pairs and dense sets of highly polymorphic markers or by emerging techniques such as genomic mismatch scanning. (GMS) is making it possible to identify the genetic etiology of a disease through detection of susceptibility loci. We present a general statistical model and test to detect disease genes, using affected relative pairs and either markers or GMS...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Chromosome Mapping
Share to Family

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genetic Linkage

Share to Genetic Markers

Share to Genome

Share to Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 8644749
PMCID: PMC1914671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A general statistical model for detecting complex-trait loci by using affected relative pairs in a genome search.PMID 8644749Read ↗

Statistical power to detect genetic (co)variance of complex traits using SNP data in unrelated samples.Semantic proximity Read ↗

Statistical properties of affected sib-pair linkage tests.Semantic proximity Read ↗

Robust multipoint identical-by-descent mapping for affected relative pairs.Semantic proximity Read ↗

Disease-driven detection of differential inherited SNP modules from SNP network.Semantic proximity Read ↗

RAPID detection of gene-gene interactions in genome-wide association studies.Semantic proximity Read ↗

Linkage analysis in the presence of errors IV: joint pseudomarker analysis of linkage and/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified.Semantic proximity Read ↗

A test statistic to detect errors in sib-pair relationships.Semantic proximity Read ↗

Genotype relative risks: methods for design and analysis of candidate-gene association studies.Semantic proximity Read ↗

Gene-based and pathway-based testing for rare-variant association in affected sib pairs.Semantic proximity Read ↗

General score tests for associations of genetic markers with disease using cases and their parents.Semantic proximity Read ↗

Massively Parallel Genetics.Semantic proximity Read ↗

Affected sibpair linkage tests for multiple linked susceptibility genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.