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Article

Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism.

Endocrinology - 1 Mar 2005

Qatanani Mohammed, Zhang Jun, Moore David D

Abstract excerpt

The induction of hepatic drug metabolizing enzymes alters not only the metabolism of the xenobiotic substances that induce them but also the metabolism of various endogenous hormones. The xenobiotic receptor constitutive androstane receptor (CAR) (NR1I3) mediates the well-studied induction of CYP2B genes and other drug-metabolizing enzymes by phenobarbital (PB), an antiepileptic drug that has been shown to alter...

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Identifiers

PMID: 15564320
DOI: 10.1210/en.2004-1350

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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