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Article

Effect of isotretinoin on CYP2D6 and CYP3A activity in patients with severe acne.

British journal of clinical pharmacology - 1 Mar 2024

Zhao Yuqian, Vary Jay C, Yadav Aprajita S, Czuba Lindsay C, Shum Sara, LaFrance Jeffrey, Huang Weize, Isoherranen Nina, Hebert Mary F

Abstract excerpt

AIMS: Previously, retinoids have decreased CYP2D6 mRNA expression in vitro and induced CYP3A4 in vitro and in vivo. This study aimed to determine whether isotretinoin administration changes CYP2D6 and CYP3A activities in patients with severe acne. METHODS: Thirty-three patients (22 females and 11 males, 23.5 ± 6.0 years old) expected to receive isotretinoin treatment completed the study. All participants were...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 37864393
DOI: 10.1111/bcp.15938
PMCID: PMC10922942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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