Article
HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. The Childhood Diabetes in Finland Study Group.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Oct 1997
Reijonen H, Nejentsev S, Tuokko J, Koskinen S, Tuomilehto-Wolf E, Akerblom H K, Ilonen J
Abstract excerpt
We determined the distribution of DR4 subtypes in 309 DQB1*0302-positive haplotypes found in insulin-dependent diabetes mellitus (IDDM) patients and 70 control haplotypes present only in healthy family members. An increased frequency of DRB1*0401 allele (74.4% vs. 55.7%, P = 0.003) and a decrease...
Topics
- Adolescent
- Alleles
- Child
- Child, Preschool
- Diabetes Mellitus, Type 1
- Disease Susceptibility
- Finland
- Gene Frequency
- Genetic Linkage
- HLA-B Antigens
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DR4 Antigen