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Increased Frequency of the HLA-DRB104:04-DQA103-DQB103:02 Haplotype Among HLA-DQB106:02-Positive Children With Type 1 Diabetes.

Diabetes - 1 Feb 2024

Ilonen Jorma, Kiviniemi Minna, El-Amir Mostafa I, Nygård Lucas, Härkönen Taina, Lempainen Johanna, Knip Mikael

Abstract excerpt

HLA-DR/DQ haplotypes largely define genetic susceptibility to type 1 diabetes (T1D). The DQB1*06:02-positive haplotype (DR15-DQ602) common in individuals of European ancestry is very rare among children with T1D. Among 4,490 children with T1D in the Finnish Pediatric Diabetes Register, 57 (1.3%) case patients with DQB1*06:02 were identified, in comparison with 26.1% of affected family-based association control...

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Identifiers

PMID: 37934957
DOI: 10.2337/db23-0387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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