Article
Specific binding of an exonic splicing enhancer by the pre-mRNA splicing factor SRp55.
RNA (New York, N.Y.) - 1 Jan 1998
Nagel R J, Lancaster A M, Zahler A M
Abstract excerpt
Purine-rich exonic splicing enhancers (ESEs) have been identified in many alternatively spliced exons. Alternative splicing of several ESE-containing exons has been shown to depend on subsets of the SR protein family of pre-mRNA splicing factors. In this report, we show that purified SR protein family member SRp55 by itself binds a 30-nt ESE-containing exon, the alternatively spliced exon 5 of avian cardiac...
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