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Article

Efficient polyadenylation of Rous sarcoma virus RNA requires the negative regulator of splicing element.

Nucleic acids research - 1 Feb 2002

Fogel Brent L, McNally Lisa M, McNally Mark T

Abstract excerpt

Rous sarcoma virus pre-mRNA contains an element known as the negative regulator of splicing (NRS) that acts to inhibit viral RNA splicing. The NRS binds serine/arginine-rich (SR) proteins, hnRNP H and the U1/U11 snRNPs, and appears to inhibit splicing by acting as a decoy 5' splice site. Deletions within the gag gene that encompass the NRS also lead to increased read-through past the viral polyadenylation site,...

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Identifiers

PMID: 11809895
DOI: 10.1093/nar/30.3.810
PMCID: PMC100303

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Source receipt: pubmed, retrieved 7 Sept 2026.

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