Article
Multiple interactions between SRm160 and SR family proteins in enhancer-dependent splicing and development of C. elegans.
Current biology : CB - 11 Dec 2001
Longman D, McGarvey T, McCracken S, Johnstone I L, Blencowe B J, Cáceres J F
Abstract excerpt
BACKGROUND: SR family and SR-related proteins assemble on exonic splicing enhancer (ESE) sequences to promote both constitutive and regulated splicing. The SRm160 splicing coactivator, an SR-related nuclear matrix protein of 160 kDa, is important for the splicing of specific constitutive and ESE-dependent pre-mRNAs. RESULTS: In the present study, we show that SRm160 is required to promote pre-mRNA splicing...
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