Article
An Intron Element Modulating 5′ Splice Site Selection in the hnRNP A1 Pre-mRNA Interacts with hnRNP A1
1 Apr 1997
Abstract excerpt
The hnRNP A1 pre-mRNA is alternatively spliced to yield the A1 and A1b mRNAs, which encode proteins differing in their ability to modulate 5' splice site selection. Sequencing a genomic portion of the murine A1 gene revealed that the intron separating exon 7 and the alternative exon 7B is highly conserved between mouse and human. In vitro splicing assays indicate that a conserved element (CE1) from the central...
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