Article
p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis.
Cancer letters - 14 May 1993
Casey G, Yamanaka Y, Friess H, Kobrin M S, Lopez M E, Buchler M, Beger H G, Korc M
Abstract excerpt
Pancreatic expression of the p53 tumor suppressor gene was studied in pancreatic adenocarcinomas and chronic pancreatitis. By immunohistochemistry, 16 of 34 (47%) cancers and none of the 24 chronic pancreatitis samples revealed nuclear staining. Sequence analysis indicated that 8 of 24 (33%) canc...
Topics
- Adenocarcinoma
- Adult
- Aged
- Amino Acid Sequence
- Base Sequence
- Chronic Disease
- Codon
- Female
- Genes, p53
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Pancreatic Neoplasms
- Pancreatitis
- Polymerase Chain Reaction
- Transcription, Genetic