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Article

p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis.

Cancer letters - 14 May 1993

Casey G, Yamanaka Y, Friess H, Kobrin M S, Lopez M E, Buchler M, Beger H G, Korc M

Abstract excerpt

Pancreatic expression of the p53 tumor suppressor gene was studied in pancreatic adenocarcinomas and chronic pancreatitis. By immunohistochemistry, 16 of 34 (47%) cancers and none of the 24 chronic pancreatitis samples revealed nuclear staining. Sequence analysis indicated that 8 of 24 (33%) cancers were mutated for the p53 gene. Point substitutions occurred at codons 35, 105, 133, 213, 213, 258, and 299. A three...

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Identifiers

PMID: 8513440
DOI: 10.1016/0304-3835(93)90168-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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