Article
Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma.
The American journal of pathology - 1 May 1994
DiGiuseppe J A, Hruban R H, Offerhaus G J, Clement M J, van den Berg F M, Cameron J L, van Mansfeld A D
Abstract excerpt
Mutations in the K-ras oncogene and in the p53 tumor suppressor gene are commonly identified in sporadic cases of pancreatic adenocarcinoma. Although these genes might serve as useful markers for early diagnosis of pancreatic carcinoma in patients at risk for the development of this disease, familial pancreatic carcinomas have not been studied for these mutations. We recently had the opportunity to examine a...
Topics
- Base Sequence
- Carcinoma
- DNA Mutational Analysis
- Female
- Genes, ras
- Humans
- Hyperplasia
- Middle Aged
- Molecular Sequence Data
- Mutation
- Pancreatic Ducts