Article
TP53 alterations in pancreatic acinar cell carcinoma: new insights into the molecular pathology of this rare cancer.
Virchows Archiv : an international journal of pathology - 1 Mar 2016
La Rosa Stefano, Bernasconi Barbara, Frattini Milo, Tibiletti Maria Grazia, Molinari Francesca, Furlan Daniela, Sahnane Nora, Vanoli Alessandro, Albarello Luca, Zhang Lizhi, Notohara Kenji, Casnedi Selenia, Chenard Marie-Pierre, Adsay Volkan, Asioli Sofia, Capella Carlo, Sessa Fausto
Abstract excerpt
The molecular alterations of pancreatic acinar cell carcinomas (ACCs) are poorly understood and have been reported as being different from those in ductal adenocarcinomas. Loss of TP53 gene function in the pathogenesis of ACCs is controversial since contradictory findings have been published. A comprehensive analysis of the different possible genetic and epigenetic mechanisms leading to TP53 alteration in ACC has...
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