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Article

Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes.

Oncogene - 1 Aug 1992

Ruggeri B, Zhang S Y, Caamano J, DiRado M, Flynn S D, Klein-Szanto A J

Abstract excerpt

The molecular pathology of human pancreatic cancer is poorly understood, particularly with regard to the role of known tumor-suppressor genes. We have examined the expression of the p53 and Rb-1 tumor-suppressor genes in seven human pancreatic carcinoma cell lines and 10 primary pancreatic carcinomas. Examination of the Rb-1 gene by Northern hybridization and immunoprecipitation analyses revealed the absence of...

Topics

Base Sequence
Blotting, Northern
Blotting, Southern
Chromosomes, Human, Pair 17
Genes, Retinoblastoma
Genes, p53
Humans
Immunohistochemistry
Molecular Sequence Data
Mutation
Pancreatic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Precipitin Tests

Tumor Cells, Cultured

Source

Identifiers

PMID: 1630814

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1630814-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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