Article
Serotonin transporter gene and risk for bipolar affective disorder: an association study in Spanish population.
Biological psychiatry - 1 Jun 1998
Gutiérrez B, Arranz M J, Collier D A, Vallès V, Guillamat R, Bertranpetit J, Murray R M, Fãnás L
Abstract excerpt
BACKGROUND: The serotonin transporter (5-HTT) is an important candidate gene for the genetic transmission of manic depressive illness. Many studies of patients with affective disorders have found abnormalities in serotonin metabolism and dysregulation of the transporter itself. In the present study, we hypothesize that genetic variation in the 5-HTT gene (17q11.1-17q12) may have an effect in the etiology of manic...
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