Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tryptophan hydroxylase gene 218A/C polymorphism is associated with somatic anxiety in major depressive disorder.

Journal of affective disorders - 1 Jun 2001

Du L, Bakish D, Hrdina P D

Abstract excerpt

BACKGROUND: Abnormalities in functioning of the central serotonergic system have been implicated in the pathogenesis of depressive illness and suicidal behavior. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin, therefore, it may play an important role in regulation or control of serotonin functions. The aim of the present investigation was to determine whether there is an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Anxiety Disorders
Share to Depressive Disorder, Major

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Polymorphism, Genetic

Share to Risk Factors

Share to Serotonin

Share to Suicide

Share to Tryptophan Hydroxylase

Source

Identifiers

PMID: 11426508
DOI: 10.1016/s0165-0327(00)00274-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tryptophan hydroxylase gene 218A/C polymorphism is associated with somatic anxiety in major depressive disorder.PMID 11426508Read ↗

TPH1 218A/C polymorphism is associated with major depressive disorder and its treatment response.Semantic proximity Read ↗

Tryptophan hydroxylase gene polymorphism (A218C) and suicidal behaviors.Semantic proximity Read ↗

Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression.Semantic proximity Read ↗

Association between the tryptophan hydroxylase gene and manic-depressive illness.Semantic proximity Read ↗

TPH2 gene polymorphisms and major depression--a meta-analysis.Semantic proximity Read ↗

Genetics of the serotonergic system in suicidal behavior.Semantic proximity Read ↗

The tryptophan hydroxylase (TPH) 2 gene unlike TPH-1 exhibits no association with stress-induced depression.Semantic proximity Read ↗

TPH1 is associated with major depressive disorder but not with SSRI/SNRI response in Taiwanese patients.Semantic proximity Read ↗

Association of tryptophan hydroxylase gene polymorphism with depression, anxiety and comorbid depression and anxiety in a population-based sample of postpartum Taiwanese women.Semantic proximity Read ↗

Tryptophan hydroxylase gene (TPH1) and peripheral tryptophan levels in depression.Semantic proximity Read ↗

Association between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders.Semantic proximity Read ↗

Haplotype analysis reveals tryptophan hydroxylase (TPH) 1 gene variants associated with major depression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.