Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients.

doi:10.1176/ajp.154.10.1451

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Article

Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients.

The American journal of psychiatry - 1 Oct 1997

Mann J J, Malone K M, Nielsen D A, Goldman D, Erdos J, Gelernter J

Abstract excerpt

OBJECTIVE: This study was designed to test the hypothesis that serotonin-system-related genes may be correlated with suicide risk. METHOD: Fifty-one unrelated Caucasian inpatients with major depression, with or without a history of suicidal acts, were genotyped for a biallelic polymorphism at the...

Topics

Adult
Alleles
Depressive Disorder
Family
Female
Gene Frequency
Hospitalization
Humans
Male
Polymorphism, Genetic
Regression Analysis
Suicide
Tryptophan Hydroxylase

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