Article
Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients.
The American journal of psychiatry - 1 Oct 1997
Mann J J, Malone K M, Nielsen D A, Goldman D, Erdos J, Gelernter J
Abstract excerpt
OBJECTIVE: This study was designed to test the hypothesis that serotonin-system-related genes may be correlated with suicide risk. METHOD: Fifty-one unrelated Caucasian inpatients with major depression, with or without a history of suicidal acts, were genotyped for a biallelic polymorphism at the tryptophan hydroxylase locus. RESULTS: The less common tryptophan hydroxylase U allele occurred with greater frequency...
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