Article
A bias-ed assessment of the use of SNPs in human complex traits.
Current opinion in genetics & development - 1 Dec 2002
Terwilliger Joseph D, Haghighi Fatemeh, Hiekkalinna Tero S, Göring Harald H H
Abstract excerpt
Although many biotechnological advancements have been made in the past decade, there has been very limited success in unraveling the genetic component of complex traits. Heavily invested research has been initiated based on etiological models of unrealistic simplicity and conducted under poor experimental designs, on data sets of insufficient size, leading to an overestimation of the effect sizes of genetic...
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