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Article

Heterogeneity of marker allele frequencies hinders interpretation of linkage analysis: illustration on chromosome 18 markers.

Genetic epidemiology - 1 Jan 1997

Margaritte-Jeannin P, Babron M C, Génin E, Eichenbaum-Voline S, Clerget-Darpoux F

Abstract excerpt

In the first part of our study we tested linkage with chromosome 18 markers in a sample of bipolar I sib pairs. We did not obtain evidence for linkage but showed that we could not exclude the presence of a disease locus (having even a non-negligible effect). The limitation of the sib-pair sample size, and consequently of the conclusions, was a result of our care in assuring that the linkage analysis was free of...

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Identifiers

PMID: 9433561
DOI: 10.1002/(SICI)1098-2272(1997)14:6<669::AID-GEPI20>3.0.CO;2-N

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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