Article
A meta-analysis of chromosome 18 linkage data for bipolar illness.
Genetic epidemiology - 1 Jan 1997
Dorr D A, Rice J P, Armstrong C, Reich T, Blehar M
Abstract excerpt
We find a meta-data set (715 families, up to 1,124 sib pairs) for bipolar illness to have a strong signal in a 10 cM region around D18S40, and excess paternal sharing on the q arm near marker D18S64. We describe a method for meta-analysis of microsatellite marker data using affected sib-pair (ASP) methodology. Inherent difficulties in such analysis include heterogeneity of allele frequencies and protocol design,...
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